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Background An estimated 257 million individuals are living with hepatitis B Virus (HBV) worldwide. While the aggregate rate of HBV infection has been firmly decreasing in the United States, Asian males continue to experience the highest risk of infection. This study aims to investigate the racial and gender disparities in HBV vaccination coverage among Asian American adults using the 2012–2015 National Health Interview Survey (NHIS). Methods The study sample included 125,399 adults aged 18 to 85 who participated in the 2012–2015 NHIS. The main outcome was HBV vaccination status. Race/ethnicity was categorized into White-non-Hispanics, Black-non-Hispanics, Hispanics, Other, Asian-Indian, Chinese, Filipino, and Other-Asian (Korean, Vietnamese, Japanese, and other Asian subgroups). Complex survey methods were applied to all models to provide statistical estimates that are representative of US adults. Multivariable logistic regression models adjusting for age, education, region of residence, survey year, health insurance access, chronic liver disease, influenza vaccination, marital, employment and health status were fit to examine the associations between gender, race/ethnicity and HBV vaccinations status. Results An estimated 39.66% (95% CI; 38.07%, 41.25%) of Asian adults living in the US received HBV vaccination. Vaccination prevalence among male Asian adults was lower than their female counterparts 38.05% (95% CI; 35.66%, 40.44%) vs. 41.09% (95% CI; 38.96%, 43.21%). Among Asian adults, the adjusted odds ratio (AOR) of HBV vaccination for females were 1.20 (95% CI; 1.04, 1.39) times higher than males. The AORs of HBV vaccinations were significantly higher when compared with white 1.21 (95% CI; 1.03, 1.41), 1.29 (95% CI; 1.10, 1.51), respectively for Chinese and Filipino Adults. We observed significant gender disparities in HBV vaccination AOR for Asian-Indian and Chinese adults. In both groups, females had higher AOR of HBV vaccination when compared with males, Asian-Indian 1.42 (95% CI; 1.04, 1.94) and Chinese 1.39 (95% CI; 1.07, 1.80). Conclusion Among Asian-Indian and Chinese adult residents of the United States, the association between race and HBV vaccination status differs by gender, with males having lower vaccination rates than females. Healthcare resources should be directed to these target populations to improve these rates. Disclosures V. Rustgi, Genfit: Grant Investigator and Investigator, Research support. Gilead: Speaker’s Bureau, Speaker honorarium. Abbvie: Speaker’s Bureau, Speaker honorarium.

2475. Hepatitis B Vaccination Coverage Amongst Asian-American Adults: A Population-Based Study of the Role of Race and Gender