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A high prevalence of late-stage disease (75.4%) and severe immunosuppression (23.3%) was observed in 155 newly diagnosed human immunodeficiency virus patients in Freetown, Sierra Leone during August to November 2017. Within the late-stage diagnosis group, a significantly high proportion of patients reported fever (84.2% vs 65.2%;  = .01), weight loss (82.2% vs 63.5%;  = .01), and malaise (89.7% vs 71.7%;  = .05). Fever was identified as the only independent predictor of late-stage disease in this study.

High Prevalence of Late-Stage Disease in Newly Diagnosed Human Immunodeficiency Virus Patients in Sierra Leone