Transcriptomic Predictors of Paradoxical Cryptococcosis-Associated Immune Reconstitution Inflammatory Syndrome | Zendy

Irina Vlasova-St. Louis | Zendy; Christina C. Chang | Zendy; S.M.A. Shahid | Zendy; Martyn A. French | Zendy; Paul R. Bohjanen | Zendy

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Transcriptomic Predictors of Paradoxical Cryptococcosis-Associated Immune Reconstitution Inflammatory Syndrome

Author(s) -

Irina Vlasova-St. Louis,

Christina C. Chang,

S.M.A. Shahid,

Martyn A. French,

Paul R. Bohjanen

Publication year - 2018

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofy157

Subject(s) - immune reconstitution inflammatory syndrome , medicine , immunology , proinflammatory cytokine , innate immune system , immune system , transcriptome , interferon , cryptococcosis , biomarker , inflammation , viral load , virus , biology , antiretroviral therapy , gene expression , gene , biochemistry

An inability to mount effective interferon-driven antiviral immune response, accompanied by a systemic granulocyte proinflammatory signature, prior to ART initiation, predisposes patients to the development of C-IRIS. Although early and late C-IRIS have seemingly similar clinical manifestations, they have different molecular phenotypes (as categorized by bioinformatics analysis) and are driven by contrasting inflammatory signaling cascades.

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