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Cellular Immune Responses 6 Years Following 1, 2, or 3 Doses of Quadrivalent HPV Vaccine in Fijian Girls and Subsequent Responses to a Dose of Bivalent HPV Vaccine
Author(s) -
Zheng Quan Toh,
Kathleen Wen Bei Cheow,
Fiona M. Russell,
Edwin Hoe,
Rita Reyburn,
James Fong,
Evelyn Tuivaga,
Felisita Tupou Ratu,
Cattram Nguyen,
Silivia Matanitobua,
Andrea Reitsma,
Sepehr N. Tabrizi,
Suzanne M. Garland,
Kim Mulholland,
Paul V. Licciardi
Publication year - 2018
Publication title -
open forum infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.546
H-Index - 35
ISSN - 2328-8957
DOI - 10.1093/ofid/ofy147
Subject(s) - medicine , elispot , immune system , immunology , cellular immunity , vaccination , peripheral blood mononuclear cell , immunity , cohort , physiology , t cell , biology , biochemistry , in vitro
These data suggest that cellular immunity following reduced-dose schedules was detectable after 6 years, although the responses were variable between HPV types and dosage groups. The clinical significance of this is unknown. Further studies on the impact of reduced dose schedules are needed, particularly in high-disease burden settings.

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