Inflammation Associates With Impaired Small Arterial Elasticity Early in HIV Disease | Zendy

Tess E. Peterson | Zendy; Katherine Huppler Hullsiek | Zendy; Nicole Engen | Zendy; Nagalingeswaran Kumarasamy | Zendy; AnneMette Lebech | Zendy; Angelike P. Liappis | Zendy; Antonios Papadopoulos | Zendy; Mark N. Polizzotto | Zendy; Pamela J. Schreiner | Zendy; Daniel Duprez | Zendy; Jason V. Baker | Zendy

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Inflammation Associates With Impaired Small Arterial Elasticity Early in HIV Disease

Author(s) -

Tess E. Peterson,

Katherine Huppler Hullsiek,

Nicole Engen,

Nagalingeswaran Kumarasamy,

AnneMette Lebech,

Angelike P. Liappis,

Antonios Papadopoulos,

Mark N. Polizzotto,

Pamela J. Schreiner,

Daniel Duprez,

Jason V. Baker

Publication year - 2018

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofy117

Subject(s) - medicine , inflammation , human immunodeficiency virus (hiv) , systemic inflammation , interleukin 6 , disease , elasticity (physics) , antiretroviral therapy , immunology , c reactive protein , cardiology , viral load , materials science , composite material

We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease.

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