Transplantation of CCR5∆32 Homozygous Umbilical Cord Blood in a Child With Acute Lymphoblastic Leukemia and Perinatally Acquired HIV Infection | Zendy

Meghan Rothenberger | Zendy; John E. Wagner | Zendy; Ashley T. Haase | Zendy; Douglas D. Richman | Zendy; Bartosz Grzywacz | Zendy; Matthew C. Strain | Zendy; Steven M. Lada | Zendy; Jacob D. Estes | Zendy; Courtney V. Fletcher | Zendy; Anthony T. Podany | Zendy; Jodi Anderson | Zendy; Thomas Schmidt | Zendy; Steve Wietgrefe | Zendy; Timothy W. Schacker | Zendy; Michael R. Verneris | Zendy

Open Access

Transplantation of CCR5∆32 Homozygous Umbilical Cord Blood in a Child With Acute Lymphoblastic Leukemia and Perinatally Acquired HIV Infection

Author(s) -

Meghan Rothenberger,

John E. Wagner,

Ashley T. Haase,

Douglas D. Richman,

Bartosz Grzywacz,

Matthew C. Strain,

Steven M. Lada,

Jacob D. Estes,

Courtney V. Fletcher,

Anthony T. Podany,

Jodi Anderson,

Thomas Schmidt,

Steve Wietgrefe,

Timothy W. Schacker,

Michael R. Verneris

Publication year - 2018

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofy090

Subject(s) - medicine , transplantation , umbilical cord , pathology , peripheral blood mononuclear cell , rectum , immunology , gastroenterology , biology , biochemistry , in vitro

HIV was detected in multiple tissues 73 days after CCR5∆32 homozygous UCB allo-HCT despite myeloablative conditioning and complete donor marrow engraftment. These results highlight the importance of analyzing tissue during HIV cure interventions and inform the choice of assay used to detect HIV in tissue reservoirs.

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