Open AccessCommon Variation in NLRP3 Is Associated With Early Death and Elevated Inflammasome Biomarkers Among Advanced HIV/TB Co-infected Patients in Botswana
Author(s) -
Shruthi Ravimohan,
Kebatshabile Nfanyana,
Neo Tamuhla,
Caroline T. Tiemessen,
Drew Weissman,
Gregory P. Bisson
Publication year - 2018
Publication title -
open forum infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.546
H-Index - 35
ISSN - 2328-8957
DOI - 10.1093/ofid/ofy075
Subject(s) - medicine , inflammasome , human immunodeficiency virus (hiv) , immunology , virology , inflammation
The rs10754558-G SNP is associated with an increased risk for early mortality in HIV/TB patients initiating ART. These patients may benefit from therapies that decrease inflammasome-mediated inflammation.
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