Emergence of Resistance to Colistin During the Treatment of Bloodstream Infection Caused by Klebsiella pneumoniae Carbapenemase–Producing Klebsiella pneumoniae | Zendy

Anubhav Kanwar | Zendy; Steven H. Marshall | Zendy; Federico Pérez | Zendy; Myreen Tomas | Zendy; Michael R. Jacobs | Zendy; Andrea M. Hujer | Zendy; Tatiana Domitrovic | Zendy; Susan D. Rudin | Zendy; Laura J. Rojas | Zendy; Barry N. Kreiswirth | Zendy; Liang Chen | Zendy; Miguel E. QuiñonesMateu | Zendy; David van Duin | Zendy; Robert A. Bonomo | Zendy

Open Access

Emergence of Resistance to Colistin During the Treatment of Bloodstream Infection Caused by Klebsiella pneumoniae Carbapenemase–Producing Klebsiella pneumoniae

Author(s) -

Anubhav Kanwar,

Steven H. Marshall,

Federico Pérez,

Myreen Tomas,

Michael R. Jacobs,

Andrea M. Hujer,

Tatiana Domitrovic,

Susan D. Rudin,

Laura J. Rojas,

Barry N. Kreiswirth,

Liang Chen,

Miguel E. QuiñonesMateu,

David van Duin,

Robert A. Bonomo

Publication year - 2018

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofy054

Subject(s) - klebsiella pneumoniae , colistin , medicine , bloodstream infection , microbiology and biotechnology , klebsiella infections , klebsiella , intensive care medicine , antibiotics , biology , escherichia coli , gene , biochemistry

We report the emergence of colistin resistance in Klebsiella pneumoniae carbapenemase (KPC)–producing Klebsiella pneumoniae after 8 days of colistin-based therapy, resulting in relapse of bloodstream infection and death. Disruption of the mgrB gene by insertion of a mobile genetic element was found to be the mechanism, which was replicated in vitro after exposure to subinhibitory concentrations of colistin and meropenem.

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