Mycobacterium abscessus Complex Infections: A Retrospective Cohort Study | Zendy

Maroun M. Sfeir | Zendy; Marissa Walsh | Zendy; Rossana Rosa | Zendy; Laura Aragon | Zendy; Sze Yan Liu | Zendy; Timothy J. Cleary | Zendy; Marylee V. Worley | Zendy; Corey M Frederick | Zendy; Lilian M. Abbo | Zendy

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Mycobacterium abscessus Complex Infections: A Retrospective Cohort Study

Author(s) -

Maroun M. Sfeir,

Marissa Walsh,

Rossana Rosa,

Laura Aragon,

Sze Yan Liu,

Timothy J. Cleary,

Marylee V. Worley,

Corey M Frederick,

Lilian M. Abbo

Publication year - 2018

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofy022

Subject(s) - medicine , mycobacterium abscessus , amikacin , retrospective cohort study , tigecycline , trimethoprim , ciprofloxacin , clarithromycin , sulfamethoxazole , nontuberculous mycobacteria , antimicrobial , surgery , antibiotics , tuberculosis , mycobacterium , pathology , microbiology and biotechnology , biology , helicobacter pylori

Our cohort of 108 complex isolates in Miami, Florida, showed an in-hospital mortality of 15.7%. Most infections were respiratory. Clarithromycin and amikacin were the most likely agents to be susceptible in vitro. Resistance to fluoroquinolone and trimethoprim/sulfamethoxazole was highly common. Macrolide resistance, immunosuppression, and renal disease were significantly associated with early treatment failure.

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