Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome
Author(s) -
Carla Bellomo,
Miša Korva,
Anna Papa,
Satu Mäkelä,
Jukka Mustonen,
Tatjana AvšičŽupanc,
Antti Vaheri,
Valeria P. Martínez,
Tomas Strandin
Publication year - 2018
Publication title -
open forum infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.546
H-Index - 35
ISSN - 2328-8957
DOI - 10.1093/ofid/ofy021
Subject(s) - medicine , hantavirus , plasminogen activator , hantavirus infection , tissue plasminogen activator , hantavirus pulmonary syndrome , plasminogen activator inhibitor 1 , immunology , virus
We analyzed the levels of circulating tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI)-1 in acute hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS). The levels of tPA commonly increased in both diseases, whereas PAI-1 correlated with disease severity in HCPS but not in HFRS.
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