Open AccessCryptococcal Disease in the Era of “Test and Treat”: Is There Cause for Concern?
Author(s) -
Mahsa Abassi,
Joshua Rhein,
David B. Meya,
David R. Boulware
Publication year - 2017
Publication title -
open forum infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.546
H-Index - 35
ISSN - 2328-8957
DOI - 10.1093/ofid/ofx274
Subject(s) - medicine , test (biology) , disease , intensive care medicine , immunology , paleontology , biology
Treatment of cryptococcosis requires deferred initiation of antiretroviral therapy (ART). Early ART initiation may be detrimental in the context of cryptococcal infection by increasing the risk of immune reconstitution inflammatory syndrome (IRIS). We present 3 cases where early ART initiation in the presence of unrecognized cryptococcal disease had fatal outcomes.
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