Acute Liver Failure Due to Echovirus 9 Associated With Persistent B-Cell Depletion From Rituximab | Zendy

Kristina L. Bajema | Zendy; Paul D. Simonson | Zendy; Alexander L. Greninger | Zendy; Başak Çoruh | Zendy; Paul S. Pottinger | Zendy; Renuka Bhattacharya | Zendy; Iris Liou | Zendy; Florencia G. Jalikis | Zendy; Corinne L. Fligner | Zendy; Robert M. Rakita | Zendy

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Acute Liver Failure Due to Echovirus 9 Associated With Persistent B-Cell Depletion From Rituximab

Author(s) -

Kristina L. Bajema,

Paul D. Simonson,

Alexander L. Greninger,

Başak Çoruh,

Paul S. Pottinger,

Renuka Bhattacharya,

Iris Liou,

Florencia G. Jalikis,

Corinne L. Fligner,

Robert M. Rakita

Publication year - 2017

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofx174

Subject(s) - medicine , rituximab , liver failure , immunology , virology , antibody

We describe a case of fatal acute liver failure due to echovirus 9 in the setting of persistent B-cell depletion and hypogammaglobulinemia 3 years after rituximab therapy. Metagenomic next-generation sequencing further specified the etiologic agent. Early recognition may provide an opportunity for interventions including intravenous immunoglobulin and liver transplantation.

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