Open AccessDisease Severity and Effective Parasite Multiplication Rate in Falciparum Malaria
Author(s) -
Hugh Kingston,
Aniruddha Ghose,
Katherine Plewes,
Haruhiko Ishioka,
Stije J. Leopold,
Richard J. Maude,
Sanjib Kanti Paul,
Benjamas Intharabut,
K. Silamut,
Charles J. Woodrow,
Nicholas Day,
Kesinee Chotivanich,
Nicholas M. Anstey,
Amir Hossain,
Nicholas J. White,
Arjen M. Dondorp
Publication year - 2017
Publication title -
open forum infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.546
H-Index - 35
ISSN - 2328-8957
DOI - 10.1093/ofid/ofx169
Subject(s) - malaria , parasitemia , plasmodium falciparum , medicine , parasite hosting , disease , immunology , world wide web , computer science
Patients presenting with severe falciparum malaria in a Bangladeshi tertiary hospital had higher total parasite burden, estimated by parasitemia and plasma PfHRP2, than uncomplicated malaria patients despite shorter fever duration. This suggests that higher parasite multiplication rates (PMR) contribute to causing the higher biomass found in severe disease. Compared with patients without a history of previous malaria, patients with previous malaria carried a lower parasite biomass with similar fever duration at presentation, suggesting that host immunity reduces the PMR.
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