Open AccessElevated Spontaneous Interferon-γ Secretion in Human Immunodeficiency Virus-Infected Persons
Author(s) -
Rachel Sparks,
David M. Koelle,
Joshua Stern,
Shireesha Dhanireddy
Publication year - 2017
Publication title -
open forum infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.546
H-Index - 35
ISSN - 2328-8957
DOI - 10.1093/ofid/ofx055
Subject(s) - medicine , human immunodeficiency virus (hiv) , interferon , immune system , virology , immunology , secretion , virus
Immune activation in human immunodeficiency virus (HIV) is a well described phenomenon. We found that HIV patients have higher secretion of interferon (IFN)-γ compared with non-HIV subjects, as measured by the "nil" value in the QuantiFERON-TB Gold test, even when viral loads are low. This may reflect ongoing immune activation, even with optimal HIV management.
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