Central Nervous System Infection Diagnosis by Next-Generation Sequencing: A Glimpse Into the Future? | Zendy

Nguyen Thi Hoang | Zendy; Nguyen Hoan Phu | Zendy; Le Nguyen Truc Nhu | Zendy; Nguyen Thi Thu Hong | Zendy; Nguyen Ho Hong Hanh | Zendy; Lam Anh Nguyet | Zendy; Tran My Phuong | Zendy; Angela McBride | Zendy; Do Quang Ha | Zendy; Ho Dang Trung Nghia | Zendy; Nguyễn Văn Vĩnh Châu | Zendy; Guy Thwaites | Zendy; Le Van Tan | Zendy

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Central Nervous System Infection Diagnosis by Next-Generation Sequencing: A Glimpse Into the Future?

Author(s) -

Nguyen Thi Hoang,

Nguyen Hoan Phu,

Le Nguyen Truc Nhu,

Nguyen Thi Thu Hong,

Nguyen Ho Hong Hanh,

Lam Anh Nguyet,

Tran My Phuong,

Angela McBride,

Do Quang Ha,

Ho Dang Trung Nghia,

Nguyễn Văn Vĩnh Châu,

Guy Thwaites,

Le Van Tan

Publication year - 2017

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofx046

Subject(s) - medicine , encephalitis , dna sequencing , metagenomics , seroconversion , virology , polymerase chain reaction , deep sequencing , japanese encephalitis , virus , biology , gene , genome , genetics

Japanese encephalitis virus was detected by deep sequencing for the first time in urine of a 16-year-old boy with encephalitis. Seroconversion and polymerase chain reaction analysis confirmed the metagenomics finding. Urine is useful for diagnosis of flaviviral encephalitis, whereas deep sequencing can be a panpathogen assay for the diagnosis of life-threatening infectious diseases.

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