Open AccessRelationship of Human Immunodeficiency Virus Viral Load in Cerebrospinal Fluid and Plasma in Patients Co-infected With Cryptococcal Meningitis
Author(s) -
Christina C. Chang,
Richard Thiga Kangethe,
Saleha Omarjee,
Keshni Hiramen,
Bernadett I. Gosnell,
Katlego Sojane,
Mohamed-Yunus S. Moosa,
Sharon R. Lewin,
Martyn A. French,
Thumbi Ndung’u
Publication year - 2017
Publication title -
open forum infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.546
H-Index - 35
ISSN - 2328-8957
DOI - 10.1093/ofid/ofx032
Subject(s) - cerebrospinal fluid , medicine , viral load , cxcl10 , immunology , virology , human immunodeficiency virus (hiv) , virus , meningitis , chemokine , immune system , pathology , psychiatry
We measured human immunodeficiency virus (HIV) ribonucleic acid (RNA) in paired cerebrospinal fluid (CSF) and plasma samples in a prospective study of 91 HIV-infected, antiretroviral therapy-naive patients with cryptococcal meningitis. Cerebrospinal fluid HIV RNA was lower than in plasma (median 4.7 vs 5.2 log copies/mL, < .0001) and positively correlated with plasma HIV RNA, peripheral CD4 T-cell percentage, and CSF CXCL10. Plasma/CSF ratio of HIV RNA ranged widely from 0.2 to 265.5 with a median of 2.6. Cerebrospinal fluid quantitative cryptococcal culture positively correlated with CSF CCL2 and CCL3. CSF-plasma viral discordance was not associated with cryptococcal-associated immune reconstitution inflammatory syndrome.
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