Hepatitis B Virus Incidence and Risk Factors Among Human Immunodeficiency Virus-1 Negative Men Who Have Sex With Men in Kenya | Zendy

Elizabeth Wahome | Zendy; Caroline Ngetsa | Zendy; John Mwambi | Zendy; Huub C. Gelderblom | Zendy; Gloria Omosa Manyonyi | Zendy; Murugi Micheni | Zendy; Amin S. Hassan | Zendy; Matt A. Price | Zendy; Susan M. Graham | Zendy; Eduard J. Sanders | Zendy

Open Access

Hepatitis B Virus Incidence and Risk Factors Among Human Immunodeficiency Virus-1 Negative Men Who Have Sex With Men in Kenya

Author(s) -

Elizabeth Wahome,

Caroline Ngetsa,

John Mwambi,

Huub C. Gelderblom,

Gloria Omosa Manyonyi,

Murugi Micheni,

Amin S. Hassan,

Matt A. Price,

Susan M. Graham,

Eduard J. Sanders

Publication year - 2016

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofw253

Subject(s) - medicine , men who have sex with men , incidence (geometry) , human immunodeficiency virus (hiv) , virology , hepatitis b virus , virus , immunology , syphilis , optics , physics

No data exist on hepatitis B virus (HBV) incidence among African men who have sex with men (MSM). We tested plasma samples archived between 2005 and 2014 for HBV core antibody or surface antigen seroconversion in a cohort of 312 initially human immunodeficiency virus (HIV)-1-negative MSM with no evidence of prior HBV infection. Hepatitis B virus incidence was 6.0/100 person-years (95% confidence interval [CI], 3.9–9.1). Hepatitis B virus acquisition was associated with being uncircumcised (adjusted incidence rate ratio [aIRR], 5.0; 95% CI, 1.5–16.8), recent HIV-1 acquisition (aIRR, 2.9; 95% CI, 1.1–7.7), rape (aIRR, 5.0; 95% CI, 1.2–20.4), and any tertiary education (aIRR, 3.2; 95% CI, 1.1–9.7). African MSM have a substantial risk of HBV acquisition and require vaccination urgently.

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