Zika Virus Causing Encephalomyelitis Associated With Immunoactivation | Zendy

Rafael Mello Galliez | Zendy; Mariana Spitz | Zendy; Patrícia Piazza Rafful | Zendy; Marcelo Cagy | Zendy; Cláudia Caminha Escosteguy | Zendy; Caroline Spósito Brito Germano | Zendy; Elisa Sasse | Zendy; Alessandro L. Gonçalves | Zendy; Paola Paz Silveira | Zendy; Paula Pezzuto | Zendy; Alice Maria de Magalhães Ornelas | Zendy; Amílcar Tanuri | Zendy; Renato Santana Aguiar | Zendy; Fernanda Tovar Moll | Zendy

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Zika Virus Causing Encephalomyelitis Associated With Immunoactivation

Author(s) -

Rafael Mello Galliez,

Mariana Spitz,

Patrícia Piazza Rafful,

Marcelo Cagy,

Cláudia Caminha Escosteguy,

Caroline Spósito Brito Germano,

Elisa Sasse,

Alessandro L. Gonçalves,

Paola Paz Silveira,

Paula Pezzuto,

Alice Maria de Magalhães Ornelas,

Amílcar Tanuri,

Renato Santana Aguiar,

Fernanda Tovar Moll

Publication year - 2016

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofw203

Subject(s) - medicine , cerebrospinal fluid , encephalomyelitis , acute disseminated encephalomyelitis , proinflammatory cytokine , zika virus , immunology , fluid attenuated inversion recovery , immune system , outbreak , virology , multiple sclerosis , virus , pathology , magnetic resonance imaging , inflammation , radiology

Brazil has experienced a Zika virus (ZIKV) outbreak with increased incidence of congenital malformations and neurological manifestations. We describe a case of a 26-year-old Brazilian Caucasian man infected with ZIKV and diagnosed with encephalomyelitis. Brain and spinal cord images showed hyperintense lesions on T2 and fluid-attenuated inversion recovery (FLAIR), and levels of proinflammatory cytokines in the cerebrospinal fluid showed a remarkable increase of interleukin (IL)-6 and IL-8. The observed pattern suggests immune activation during the acute phase, along with the neurological impairment, with normalization in the recovery phase. This is the first longitudinal report of ZIKV infection causing encephalomyelitis with documented immune activation.

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