Continued Sensitivity of Plasmodium falciparum to Artemisinin in Guyana, With Absence of Kelch Propeller Domain Mutant Alleles | Zendy

Reyaud Rahman | Zendy; Marı́a J. Martı́n | Zendy; Shamdeo Persaud | Zendy; Nicolas Ceron | Zendy; Dwayne Kellman | Zendy; L. Musset | Zendy; Keith H. Carter | Zendy; Pascal Ringwald | Zendy

Open Access

Continued Sensitivity of Plasmodium falciparum to Artemisinin in Guyana, With Absence of Kelch Propeller Domain Mutant Alleles

Author(s) -

Reyaud Rahman,

Marı́a J. Martı́n,

Shamdeo Persaud,

Nicolas Ceron,

Dwayne Kellman,

L. Musset,

Keith H. Carter,

Pascal Ringwald

Publication year - 2016

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofw185

Subject(s) - plasmodium falciparum , artemisinin , mutant , medicine , propeller , virology , malaria , domain (mathematical analysis) , genetics , biology , immunology , gene , mathematical analysis , mathematics , marine engineering , engineering

Because of concerns about possible emergence of artemisinin resistance strains of Plasmodium falciparum in mining areas of the interior of Guyana, a 7-day artesunate trial was conducted from March to December 2014. The day-3 parasite clearance rate, the efficacy of artesunate at day 28, and polymorphism of Kelch 13 ( PfK13 )—the marker of artemisinin resistance—were assessed. The study confirmed the continued sensitivity of P falciparum to artemisinin. A 7-day course of artesunate was 100% efficacious with only 2% (95% confidence interval, .1%–10.9%) of enrolled subjects positive at day 3. All day-0 parasite samples were wild type. Continued resistance monitoring is nevertheless recommended, given the widespread availability and uncontrolled use of artemisinin drugs in mining areas of Guyana.

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