Performance of a Novel Plasma-Based Next-Generation Sequencing Assay in Patients With Bacteremia | Zendy

David K. Hong | Zendy; Mickey Kertesz | Zendy; Tim Blauwkamp | Zendy; Cynthia Truong | Zendy; Niaz Banaei | Zendy

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Performance of a Novel Plasma-Based Next-Generation Sequencing Assay in Patients With Bacteremia

Author(s) -

David K. Hong,

Mickey Kertesz,

Tim Blauwkamp,

Cynthia Truong,

Niaz Banaei

Publication year - 2016

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofw172.36

Subject(s) - medicine , bacteremia , dna sequencing , computational biology , oncology , intensive care medicine , bioinformatics , microbiology and biotechnology , genetics , gene , antibiotics , biology

Other: Lactobacillus paracasei, Citrobacter freundii, Morganella morgani, Streptococcus pyogenes, Salmonella enterica, Serratia marcescens, Rothia mucilaginosa 7 Background: Blood cultures are routinely obtained during the diagnostic evaluation for a number of infectious conditions such as sepsis, febrile neutropenia, and pneumonia. Despite its ubiquitous use, blood cultures have poor sensitivity due to a number of factors including previous antibiotic therapy or the presence of poorly-growing fastidious organisms. There is a need for more comprehensive diagnostic tests that can overcome these limitations to aid in guiding therapy.

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