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Carbapenem resistant organisms (CROs) have emerged as a public health crisis because of high rates of mortality and morbidity. Epidemiologic and clinical factors contributing to patient outcomes vary. Objectives included evaluating emergence of CROs, and identifying factors associated with patient mortality at UPMC Presbyterian hospital. Microbiology records were extracted from the most common gram-negative pathogens, E.coli(Ecol), Klebsiella pneumoniae(Klpn), Pseudomonas aeruginosa(Psar), Enterobacter aerogenes/cloacae(Entb), Serratia marcescens(Serm), and Acinetobacter baumannii(Acat) from 2000-2015. We identified 84,597 isolates from 37,823 patients. Among all isolates 9.5% (8,864) were classified as CROs. Standardized by patient, 7.5% of isolates were CR in 2000, 14.6% in 2015 (P

Emerging Waves of Carbapenem Resistance Among Gram-Negative Pathogens at a Tertiary Center