Emerging Waves of Carbapenem Resistance Among Gram-Negative Pathogens at a Tertiary Center | Zendy

Ryan K. Shields | Zendy; Lloyd Clarke | Zendy; Julie Paronish | Zendy; Cornelius J. Clancy | Zendy; M. Hong Nguyen | Zendy

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Emerging Waves of Carbapenem Resistance Among Gram-Negative Pathogens at a Tertiary Center

Author(s) -

Ryan K. Shields,

Lloyd Clarke,

Julie Paronish,

Cornelius J. Clancy,

M. Hong Nguyen

Publication year - 2016

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofw172.223

Subject(s) - enterobacter aerogenes , acinetobacter baumannii , medicine , pseudomonas aeruginosa , klebsiella pneumoniae , serratia marcescens , microbiology and biotechnology , enterobacter cloacae , carbapenem , gram , acinetobacter , antibiotics , biology , bacteria , genetics , biochemistry , escherichia coli , gene

Carbapenem resistant organisms (CROs) have emerged as a public health crisis because of high rates of mortality and morbidity. Epidemiologic and clinical factors contributing to patient outcomes vary. Objectives included evaluating emergence of CROs, and identifying factors associated with patient mortality at UPMC Presbyterian hospital. Microbiology records were extracted from the most common gram-negative pathogens, E.coli(Ecol), Klebsiella pneumoniae(Klpn), Pseudomonas aeruginosa(Psar), Enterobacter aerogenes/cloacae(Entb), Serratia marcescens(Serm), and Acinetobacter baumannii(Acat) from 2000-2015. We identified 84,597 isolates from 37,823 patients. Among all isolates 9.5% (8,864) were classified as CROs. Standardized by patient, 7.5% of isolates were CR in 2000, 14.6% in 2015 (P

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