Increase in Middle East Respiratory Syndrome-Coronavirus Cases in Saudi Arabia Linked to Hospital Outbreak With Continued Circulation of Recombinant Virus, July 1–August 31, 2015 | Zendy

Abdullah M. Assiri | Zendy; Holly M. Biggs | Zendy; Glen R. Abedi | Zendy; Xiaoyan Lu | Zendy; Abdulaziz Bin Saeed | Zendy; Osman Abdalla | Zendy; Mutaz Mohammed | Zendy; Hail M. Al-Abdely | Zendy; Homoud S. Algarni | Zendy; Raafat F. Alhakeem | Zendy; Malak Almasri | Zendy; Ali A. Alsharef | Zendy; Randa Nooh | Zendy; Dean D. Erdman | Zendy; Susan I. Gerber | Zendy; John T. Watson | Zendy

Open Access

Increase in Middle East Respiratory Syndrome-Coronavirus Cases in Saudi Arabia Linked to Hospital Outbreak With Continued Circulation of Recombinant Virus, July 1–August 31, 2015

Author(s) -

Abdullah M. Assiri,

Holly M. Biggs,

Glen R. Abedi,

Xiaoyan Lu,

Abdulaziz Bin Saeed,

Osman Abdalla,

Mutaz Mohammed,

Hail M. Al-Abdely,

Homoud S. Algarni,

Raafat F. Alhakeem,

Malak Almasri,

Ali A. Alsharef,

Randa Nooh,

Dean D. Erdman,

Susan I. Gerber,

John T. Watson

Publication year - 2016

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

ISSN - 2328-8957

DOI - 10.1093/ofid/ofw165

Subject(s) - outbreak , medicine , virology , middle east respiratory syndrome coronavirus , frameshift mutation , transmission (telecommunications) , virus , middle east respiratory syndrome , covid-19 , pediatrics , biology , genetics , disease , mutation , gene , infectious disease (medical specialty) , electrical engineering , engineering

During July–August 2015, the number of cases of Middle East respiratory syndrome (MERS) reported from Saudi Arabia increased dramatically. We reviewed the 143 confirmed cases from this period and classified each based upon likely transmission source. We found that the surge in cases resulted predominantly (90%) from secondary transmission largely attributable to an outbreak at a single healthcare facility in Riyadh. Genome sequencing of MERS coronavirus from 6 cases demonstrated continued circulation of the recently described recombinant virus. A single unique frameshift deletion in open reading frame 5 was detected in the viral sequence from 1 case.

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