Candida albicans Transcriptional Profiling Within Biliary Fluid From a Patient With Cholangitis, Before and After Antifungal Treatment and Surgical Drainage | Zendy

Cornelius J. Clancy | Zendy; Camille Meslin | Zendy; Hassan Badrane | Zendy; Shaoji Cheng | Zendy; Liliana Losada | Zendy; William C. Nierman | Zendy; Pascalis Vergidis | Zendy; Nathan L. Clark | Zendy; M. Hong Nguyen | Zendy

Open Access

Candida albicans Transcriptional Profiling Within Biliary Fluid From a Patient With Cholangitis, Before and After Antifungal Treatment and Surgical Drainage

Author(s) -

Cornelius J. Clancy,

Camille Meslin,

Hassan Badrane,

Shaoji Cheng,

Liliana Losada,

William C. Nierman,

Pascalis Vergidis,

Nathan L. Clark,

M. Hong Nguyen

Publication year - 2016

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofw120

Subject(s) - medicine , candida albicans , antifungal , profiling (computer programming) , biliary drainage , intensive care medicine , surgery , microbiology and biotechnology , dermatology , biology , computer science , operating system

We used ribonucleic acid sequencing to profile Candida albicans transcription within biliary fluid from a patient with cholangitis; samples were collected before and after treatment with fluconazole and drainage. Candida albicans transcriptomes at the infection site distinguished treated from untreated cholangitis. After treatment, 1131 C. albicans genes were differentially expressed in biliary fluid. Up-regulated genes were enriched in hyphal growth, cell wall organization, adhesion, oxidation reduction, biofilm, and fatty acid and ergosterol biosynthesis. This is the first study to define Candida global gene expression during deep-seated human infection. Successful treatment of cholangitis induced C. albicans genes involved in fluconazole responses and pathogenesis

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