Disseminated Talaromyces marneffei and Mycobacterium abscessus in a Patient With Anti-Interferon-γ Autoantibodies | Zendy

Nattapol Pruetpongpun | Zendy; Thana Khawcharoenporn | Zendy; Pansachee Damronglerd | Zendy; Worapop Suthiwartnarueput | Zendy; Anucha Apisarnthanarak | Zendy; Sasinuch Rujanavej | Zendy; Nuntra Suwantarat | Zendy

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Disseminated Talaromyces marneffei and Mycobacterium abscessus in a Patient With Anti-Interferon-γ Autoantibodies

Author(s) -

Nattapol Pruetpongpun,

Thana Khawcharoenporn,

Pansachee Damronglerd,

Worapop Suthiwartnarueput,

Anucha Apisarnthanarak,

Sasinuch Rujanavej,

Nuntra Suwantarat

Publication year - 2016

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofw093

Subject(s) - medicine , autoantibody , penicillium marneffei , mycobacterium abscessus , immunology , rituximab , mycobacterium , human immunodeficiency virus (hiv) , immunodeficiency , interferon , microbiology and biotechnology , antimicrobial , virology , antibody , immune system , biology , pathology , coinfection , tuberculosis

Anti-interferon (IFN)-γ autoantibodies are increasingly recognized as a cause of adult-onset immunodeficiency and increased risk for infections with intracellular pathogens. We report on disseminated Talaromyces (Penicillium) marneffei and Mycobacterium abscessus infection in a 72-year-old, human immunodeficiency virus noninfected, Thai man with anti-IFN-γ autoantibody. The patient was successfully treated with antimicrobial therapy and rituximab to control B cell-derived autoantibodies.

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