Long-Term Control of Human Immunodeficiency Virus-1 Replication Despite Extensive Resistance to Current Antiretroviral Regimens: Clonal Analysis of Resistance Mutations in Proviral Deoxyribonucleic Acid | Zendy

Natalia Stella-Ascariz | Zendy; Rocío Montejano | Zendy; María MartinVicente | Zendy; Jesús Mingorance | Zendy; Ignacio Valero | Zendy; José I. Bernardino | Zendy; José Ramón Arribas | Zendy

Open Access

Long-Term Control of Human Immunodeficiency Virus-1 Replication Despite Extensive Resistance to Current Antiretroviral Regimens: Clonal Analysis of Resistance Mutations in Proviral Deoxyribonucleic Acid

Author(s) -

Natalia Stella-Ascariz,

Rocío Montejano,

María MartinVicente,

Jesús Mingorance,

Ignacio Valero,

José I. Bernardino,

José Ramón Arribas

Publication year - 2016

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofw041

Subject(s) - virology , regimen , medicine , human immunodeficiency virus (hiv) , mutation , virus , antiretroviral therapy , viral replication , drug resistance , biology , viral load , microbiology and biotechnology , genetics , gene

Archived resistance mutations compromise antiretroviral treatment. We have investigated 3 selected aviremic patients who had extensive historical resistance to their current regimen. All 3 patients underwent unstructured treatment interruptions associated to the re-emergence of wild-type virus before starting their current suppressive regimes. Almost all historical resistance mutations detected in plasma were found in circulating proviral deoxyribonucleic acid. None of the clones analyzed was fully resistant to the current antiretroviral regimen.

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