Malignancies, Particularly B-Cell Lymphomas, Are a Frequent Cause of Mortality in Human Immunodeficiency Virus-1 Patients Despite Highly Active Antiretroviral Therapy | Zendy

Daniel O. Griffin | Zendy; Michael J. Metzger | Zendy; Kaitlin Poeth | Zendy; Kathy Deng | Zendy; Arif Dharsee | Zendy; Juan Carlos Rico | Zendy; Joseph P. McGowan | Zendy

Open Access

Malignancies, Particularly B-Cell Lymphomas, Are a Frequent Cause of Mortality in Human Immunodeficiency Virus-1 Patients Despite Highly Active Antiretroviral Therapy

Author(s) -

Daniel O. Griffin,

Michael J. Metzger,

Kaitlin Poeth,

Kathy Deng,

Arif Dharsee,

Juan Carlos Rico,

Joseph P. McGowan

Publication year - 2015

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofv147

Subject(s) - medicine , malignancy , cohort , life expectancy , human immunodeficiency virus (hiv) , cancer , antiretroviral therapy , lymphoma , mortality rate , cause of death , immunodeficiency , immunology , viral load , population , disease , immune system , environmental health

Human immunodeficiency virus (HIV)-1-infected individuals are affected by diseases at rates above those of their HIV-negative peers despite the increased life expectancy of the highly active antiretroviral therapy era. We followed a cohort of approximately 2000 HIV-1-infected patients for 5 years. The most frequent cause of death in this HIV-1-infected cohort was malignancy, with 39% of all classified deaths due to cancer. Among the cancer deaths, B-cell lymphomas were the most commonly seen malignancy, representing 34% of all cancer deaths. These lymphomas were very aggressive with a median survival of <2 months from time of diagnosis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research