Hemophagocytic Lymphohistiocytosis Secondary to Human Immunodeficiency Virus-Associated Histoplasmosis | Zendy

Anthony A. Castelli | Zendy; David G. Rosenthal | Zendy; Rachel Bender Ignacio | Zendy; Helen Y. Chu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Hemophagocytic Lymphohistiocytosis Secondary to Human Immunodeficiency Virus-Associated Histoplasmosis

Author(s) -

Anthony A. Castelli,

David G. Rosenthal,

Rachel Bender Ignacio,

Helen Y. Chu

Publication year - 2015

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofv140

Subject(s) - hemophagocytic lymphohistiocytosis , fulminant , medicine , histoplasmosis , immunology , immunodeficiency , bacteremia , human immunodeficiency virus (hiv) , immune system , virology , antibiotics , disease , pathology , microbiology and biotechnology , biology

Hemophagocytic lymphohistiocytosis (HLH) in immunocompromised hosts is a fulminant syndrome of immune activation with high rates of mortality that may be triggered by infections or immunodeficiency. Rapid diagnosis and treatment of the underlying disorder is necessary to prevent progression to multiorgan failure and death. We report a case of HLH in a patient with human immunodeficiency virus, disseminated histoplasmosis, Mycobacterium avium complex, and Escherichia coli bacteremia. We discuss management of acutely ill patients with HLH and treatment of the underlying infection versus initiation of HLH-specific chemotherapy.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research