Interpretation of Negative Molecular Test Results in Patients With Suspected or Confirmed Ebola Virus Disease: Report of Two Cases | Zendy

Jeffrey K. Edwards | Zendy; Christian Kleine | Zendy; Vincent J. Munster | Zendy; Ruggero Giuliani | Zendy; Moses Massaquoi | Zendy; Armand Sprecher | Zendy; Daniel S. Chertow | Zendy

Open Access

Interpretation of Negative Molecular Test Results in Patients With Suspected or Confirmed Ebola Virus Disease: Report of Two Cases

Author(s) -

Jeffrey K. Edwards,

Christian Kleine,

Vincent J. Munster,

Ruggero Giuliani,

Moses Massaquoi,

Armand Sprecher,

Daniel S. Chertow

Publication year - 2015

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofv137

Subject(s) - medicine , ebola virus , ebolavirus , test (biology) , disease , interpretation (philosophy) , virology , paleontology , computer science , biology , programming language

Quantitative reverse-transcription polymerase chain reaction (qRT-PCR) is the most sensitive quantitative diagnostic assay for detection of Ebola virus in multiple body fluids. Despite the strengths of this assay, we present 2 cases of Ebola virus disease (EVD) and highlight the potential for false-negative results during the early and late stages of EVD. The first case emphasizes the low negative-predictive value of qRT-PCR during incubation and the early febrile stage of EVD, and the second case emphasizes the potential for false-negative results during recovery and late neurologic complications of EVD. Careful interpretation of test results are needed to guide difficult admission and discharge decisions in suspected or confirmed EVD.

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