Extensive Recruitment of Plasma Blasts to the Cerebrospinal Fluid in Toscana Virus Encephalitis | Zendy

Lucas Schirmer | Zendy; Silke Wölfel | Zendy; Enrico Georgi | Zendy; Markus Ploner | Zendy; B. Bauer | Zendy; Bernhard Hemmer | Zendy

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Extensive Recruitment of Plasma Blasts to the Cerebrospinal Fluid in Toscana Virus Encephalitis

Author(s) -

Lucas Schirmer,

Silke Wölfel,

Enrico Georgi,

Markus Ploner,

B. Bauer,

Bernhard Hemmer

Publication year - 2015

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofv124

Subject(s) - cerebrospinal fluid , virology , medicine , polymerase chain reaction , encephalitis , virus , serology , pathology , immunology , biology , gene , antibody , biochemistry

An unexpectedly extensive recruitment of B cells and plasma blasts to the cerebrospinal fluid (CSF) in a patient with Toscana virus (TOSV) encephalitis is described. Acute infection by TOSV was demonstrated by serological methods and by detection of TOSV-specific nucleic acid in the CSF by real-time polymerase chain reaction and sequencing.

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