Strong Impact of Smoking on Multimorbidity and Cardiovascular Risk Among Human Immunodeficiency Virus-Infected Individuals in Comparison With the General Population | Zendy

Barbara Hasse | Zendy; Philip Tarr | Zendy; Pedro MarquesVidal | Zendy; Gérard Waeber | Zendy; Martin Preisig | Zendy; Vincent Mooser | Zendy; Fabio Valeri | Zendy; Sima Djalali | Zendy; Andri Rauch | Zendy; Enos Bernasconi | Zendy; Alexandra Calmy | Zendy; Matthias Cavassini | Zendy; Pietro Vernazza | Zendy; Manuel Battegay | Zendy; Rainer Weber | Zendy; Oliver Senn | Zendy; Péter Vollenweider | Zendy; Bruno Ledergerber | Zendy; Vincent Aubert | Zendy; Julia M. I. Barth | Zendy; Jürg Böni | Zendy; H C Bucher | Zendy; Claudine BurtonJeangros | Zendy; Matthias Egger | Zendy; Luigia Elzi | Zendy; Jan Fehr | Zendy; Jacques Fellay | Zendy; Hansjakob Furrer | Zendy; C A Fux | Zendy; Meri Gorgievski | Zendy; Huldrych F. Günthard | Zendy; David Haerry | Zendy; Hans H. Hirsch | Zendy; Irène Hösli | Zendy; Christian R. Kahlert | Zendy; Laurent Kaiser | Zendy; Olivia Keiser | Zendy; Thomas Klimkait | Zendy; Roger D. Kouyos | Zendy; Helen Kovari | Zendy; G Martinetti | Zendy; Begoña Martínez de Tejada | Zendy; Karin J. Metzner | Zendy; Nicolas Müller | Zendy; David Nadal | Zendy; G Pantaleo | Zendy; Stephan Regenass | Zendy; Martin Rickenbach | Zendy; Christoph Rudin | Zendy; F. Schöni-Affolter | Zendy; Patrick Schmid | Zendy; D. Schultze | Zendy; Jörg Schüpbach | Zendy; Roberto F. Speck | Zendy; Cornelia Staehelin | Zendy; Amalio Telenti | Zendy; Alexandra Trkola | Zendy; Sabine Yerly | Zendy; Aubry Jean-Michel | Zendy; Murielle Bochud | Zendy; Gaspoz Jean Michel | Zendy; Christoph Hock | Zendy; Lüscher Thomas | Zendy; Marques Vidal Pedro | Zendy; Fred Paccaud | Zendy; Preisig Martin | Zendy; Von Känel Roland | Zendy; Vladeta Aidacic | Zendy; Waeber Gerard | Zendy; Beriger Jürg | Zendy; Bertschi Markus | Zendy; Heinz Bhend | Zendy; Martin Büchi | Zendy; Bürke Hans-Ulrich | Zendy; Bugmann Ivo | Zendy; Cadisch Reto | Zendy; C. Isabelle | Zendy; Chmiel Corinne | Zendy; Deborah Ibechone Peter | Zendy; Erni Simone | Zendy; Forster Andrea | Zendy; Frei Markus | Zendy; Frey Claudius | Zendy; Frey Jakob | Zendy; Gibreil Musa Ali | Zendy; Günthard Matthias | Zendy; Haller Denis | Zendy; Hanselmann Marcel | Zendy; H. Backes Walter | Zendy; Heininger Simon | Zendy; Huber Felix | Zendy; Hufschmid Paul | Zendy; Kaiser Eva | Zendy; K Khavinson Vladimir | Zendy; Klaus Daniel | Zendy; Koch Stephan | Zendy; Köstner Beat | Zendy; Kuster Benedict | Zendy; Kuster Heidi | Zendy; Ladan Vesna | Zendy; Lauffer Giovanni | Zendy; L. Werner | Zendy; Luchsinger Phillippe | Zendy; Lüscher Severin | Zendy; Christoph Maier | Zendy; Martin Jürgen | Zendy; Meli Damian | Zendy; Messerli Werner | Zendy; Morger Titus | Zendy; Navarro Valentina | Zendy; Rizzi Jakob | Zendy; Thomas Rosemann | Zendy; Sajdl Hana | Zendy; Schindelek Frank | Zendy; Schlatter Georg | Zendy; Senn Oliver | Zendy; Somaini Pietro | Zendy; Staeger Jacques | Zendy; Alfred Staehelin | Zendy; Steinegger Alois | Zendy; Steurer Claudia | Zendy; Suter Othmar | Zendy; Truong The Phuoc | Zendy; Vecellio Marco | Zendy; Violi Alessandro | Zendy; Von Allmen René | Zendy; Waeckerlin Hans | Zendy; Weber Fritz | Zendy; W. A. M. Celie Johanna | Zendy; Widler Joseph | Zendy; Marco Zoller | Zendy

Open Access

Strong Impact of Smoking on Multimorbidity and Cardiovascular Risk Among Human Immunodeficiency Virus-Infected Individuals in Comparison With the General Population

Author(s) -

Barbara Hasse,

Philip Tarr,

Pedro MarquesVidal,

Gérard Waeber,

Martin Preisig,

Vincent Mooser,

Fabio Valeri,

Sima Djalali,

Andri Rauch,

Enos Bernasconi,

Alexandra Calmy,

Matthias Cavassini,

Pietro Vernazza,

Manuel Battegay,

Rainer Weber,

Oliver Senn,

Péter Vollenweider,

Bruno Ledergerber,

Vincent Aubert,

Julia M. I. Barth,

Jürg Böni,

H C Bucher,

Claudine BurtonJeangros,

Matthias Egger,

Luigia Elzi,

Jan Fehr,

Jacques Fellay,

Hansjakob Furrer,

C A Fux,

Meri Gorgievski,

Huldrych F. Günthard,

David Haerry,

Hans H. Hirsch,

Irène Hösli,

Christian R. Kahlert,

Laurent Kaiser,

Olivia Keiser,

Thomas Klimkait,

Roger D. Kouyos,

Helen Kovari,

G Martinetti,

Begoña Martínez de Tejada,

Karin J. Metzner,

Nicolas Müller,

David Nadal,

G Pantaleo,

Stephan Regenass,

Martin Rickenbach,

Christoph Rudin,

F. Schöni-Affolter,

Patrick Schmid,

D. Schultze,

Jörg Schüpbach,

Roberto F. Speck,

Cornelia Staehelin,

Amalio Telenti,

Alexandra Trkola,

Sabine Yerly,

Aubry Jean-Michel,

Murielle Bochud,

Gaspoz Jean Michel,

Christoph Hock,

Lüscher Thomas,

Marques Vidal Pedro,

Fred Paccaud,

Preisig Martin,

Von Känel Roland,

Vladeta Aidacic,

Waeber Gerard,

Beriger Jürg,

Bertschi Markus,

Heinz Bhend,

Martin Büchi,

Bürke Hans-Ulrich,

Bugmann Ivo,

Cadisch Reto,

C. Isabelle,

Chmiel Corinne,

Deborah Ibechone Peter,

Erni Simone,

Forster Andrea,

Frei Markus,

Frey Claudius,

Frey Jakob,

Gibreil Musa Ali,

Günthard Matthias,

Haller Denis,

Hanselmann Marcel,

H. Backes Walter,

Heininger Simon,

Huber Felix,

Hufschmid Paul,

Kaiser Eva,

K Khavinson Vladimir,

Klaus Daniel,

Koch Stephan,

Köstner Beat,

Kuster Benedict,

Kuster Heidi,

Ladan Vesna,

Lauffer Giovanni,

L. Werner,

Luchsinger Phillippe,

Lüscher Severin,

Christoph Maier,

Martin Jürgen,

Meli Damian,

Messerli Werner,

Morger Titus,

Navarro Valentina,

Rizzi Jakob,

Thomas Rosemann,

Sajdl Hana,

Schindelek Frank,

Schlatter Georg,

Senn Oliver,

Somaini Pietro,

Staeger Jacques,

Alfred Staehelin,

Steinegger Alois,

Steurer Claudia,

Suter Othmar,

Truong The Phuoc,

Vecellio Marco,

Violi Alessandro,

Von Allmen René,

Waeckerlin Hans,

Weber Fritz,

W. A. M. Celie Johanna,

Widler Joseph,

Marco Zoller

Publication year - 2015

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofv108

Subject(s) - medicine , human immunodeficiency virus (hiv) , population , multimorbidity , virology , immunology , gerontology , environmental health

Background. Although acquired immune deficiency syndrome-associated morbidity has diminished due to excellent viral control, multimorbidity may be increasing among human immunodeficiency virus (HIV)-infected persons compared with the general population. Methods. We assessed the prevalence of comorbidities and multimorbidity in participants of the Swiss HIV Cohort Study (SHCS) compared with the population-based CoLaus study and the primary care-based FIRE (Family Medicine ICPC-Research using Electronic Medical Records) records. The incidence of the respective endpoints were assessed among SHCS and CoLaus participants. Poisson regression models were adjusted for age, sex, body mass index, and smoking. Results. Overall, 74 291 participants contributed data to prevalence analyses (3230 HIV-infected; 71 061 controls). In CoLaus, FIRE, and SHCS, multimorbidity was present among 26%, 13%, and 27% of participants. Compared with nonsmoking individuals from CoLaus, the incidence of cardiovascular disease was elevated among smoking individuals but independent of HIV status (HIV-negative smoking: incidence rate ratio [IRR] = 1.7, 95% confidence interval [CI] = 1.2-2.5; HIV-positive smoking: IRR = 1.7, 95% CI = 1.1-2.6; HIV-positive nonsmoking: IRR = 0.79, 95% CI = 0.44-1.4). Compared with nonsmoking HIV-negative persons, multivariable Poisson regression identified associations of HIV infection with hypertension (nonsmoking: IRR = 1.9, 95% CI = 1.5-2.4; smoking: IRR = 2.0, 95% CI = 1.6-2.4), kidney (nonsmoking: IRR = 2.7, 95% CI = 1.9-3.8; smoking: IRR = 2.6, 95% CI = 1.9-3.6), and liver disease (nonsmoking: IRR = 1.8, 95% CI = 1.4-2.4; smoking: IRR = 1.7, 95% CI = 1.4-2.2). No evidence was found for an association of HIV-infection or smoking with diabetes mellitus. Conclusions. Multimorbidity is more prevalent and incident in HIV-positive compared with HIV-negative individuals. Smoking, but not HIV status, has a strong impact on cardiovascular risk and multimorbidity

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