Open AccessReactivation of Chagas Disease in a Patient With Follicular Lymphoma Diagnosed by Means of Quantitative Real-Time Polymerase Chain Reaction
Author(s) -
María Isabel Garzón,
Ariel German Sánchez,
Maria C. Goy,
Teresita Alvarellos,
Abel Zárate,
Ana Lisa Basquiera,
Juan José García,
Juan Pablo Caeiro
Publication year - 2015
Publication title -
open forum infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.546
H-Index - 35
ISSN - 2328-8957
DOI - 10.1093/ofid/ofv060
Subject(s) - medicine , follicular lymphoma , chagas disease , benznidazole , prednisone , asymptomatic , lymphoma , gastroenterology , rituximab , real time polymerase chain reaction , vincristine , chemotherapy , immunology , cyclophosphamide , trypanosoma cruzi , biology , parasite hosting , biochemistry , world wide web , computer science , gene
We report a case of Chagas disease reactivation in a patient with stage IIb follicular lymphoma in the cecum. He was admitted to the hospital with neutropenia and fever. He had a history of right hemicolectomy 6 months earlier and had received the sixth cycle of chemotherapy with cyclophosphamide/doxorubicin/vincristine/prednisone/rituximab. Blood and urine cultures were negative, but the fever persisted. Reactivation of Chagas disease was confirmed by means of quantitative real-time polymerase chain reaction (qRT-PCR). Parasitic load was 577 950 parasite equivalents/mL. The patient began treatment with benznidazole 5 mg/k per day every 12 hours. After 1 month, the qRT-PCR control was undetectable. The patient completed 60 days of treatment and is currently asymptomatic. Trypanosoma cruzi qRT-PCR may become a useful diagnostic method for reactivation of Chagas disease.
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