Open AccessA Human Immunodeficiency Virus Controller With a Large Population of CD4+CD8+ Double-Positive T Cells
Author(s) -
Christine M. Durand,
Robert W. Buckheit,
María Salgado,
Christopher W. Pohlmeyer,
Victoria E. Walker-Sperling,
Robert W. Hegarty,
Richard F. Ambinder,
Joel N. Blankson
Publication year - 2015
Publication title -
open forum infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.546
H-Index - 35
ISSN - 2328-8957
DOI - 10.1093/ofid/ofv039
Subject(s) - virology , human immunodeficiency virus (hiv) , cd8 , virus , viral replication , cytotoxic t cell , medicine , population , antiretroviral therapy , immunology , viral load , biology , immune system , in vitro , genetics , environmental health
Human immunodeficiency virus (HIV) controllers are patients who control viral replication without antiretroviral therapy. We present the case of an HIV controller who had CD4 and CD8 coexpressed on 40% of his T cells. Although a recent study found that double-positive T cells had superior antiviral capacity in HIV-1 controllers, in this case, the CD4(+)CD8(+) T cells did not have strong antiviral activity.