Adult T-Cell Leukemia/Lymphoma in a Caucasian Patient After Sexual Transmission of Human T-Cell Lymphotropic Virus Type 1 | Zendy

David Sibon | Zendy; Olivier Cassar | Zendy; I. Duga | Zendy; Chantal Brouzes | Zendy; David Ghez | Zendy; Christophe Pasquier | Zendy; Claire Sibon | Zendy; Alexandra Desrames | Zendy; Franck Mortreux | Zendy; Eric Wattel | Zendy; Ali Bazarbachi | Zendy; Antoine Gessain | Zendy; Olivier Hermine | Zendy

Open Access

Adult T-Cell Leukemia/Lymphoma in a Caucasian Patient After Sexual Transmission of Human T-Cell Lymphotropic Virus Type 1

Author(s) -

David Sibon,

Olivier Cassar,

I. Duga,

Chantal Brouzes,

David Ghez,

Christophe Pasquier,

Claire Sibon,

Alexandra Desrames,

Franck Mortreux,

Eric Wattel,

Ali Bazarbachi,

Antoine Gessain,

Olivier Hermine

Publication year - 2015

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofv032

Subject(s) - medicine , leukemia , transmission (telecommunications) , sexual transmission , lymphoma , virology , human t lymphotropic virus 1 , virus , genotyping , breastfeeding , adult t cell leukemia/lymphoma , deltaretrovirus , t cell leukemia , immunology , viral disease , human immunodeficiency virus (hiv) , pediatrics , genotype , biology , biochemistry , microbicide , engineering , gene , electrical engineering

International audienceAdult T-cell leukemia/lymphoma (ATLL), a T-cell neoplasm caused by human T-cell lymphotropic virus type 1 (HTLV-1), develops in the majority of cases in individuals who were infected with HTLV-1 as young children, by their mother during prolonged breastfeeding. We report the case of a Caucasian French man, whose parents were HTLV-1-seronegative and who developed ATLL after HTLV-1 sexual transmission by a Cameroonian woman. This hypothesis was corroborated by genotyping of the patient's virus, which revealed an HTLV-1B strain, found only in Central Africa, especially in Cameroon. Thus, ATLL may develop after HTLV-1 infection during adulthood, outside breastfeeding

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