Longitudinal Analysis of SARS-CoV-2 Vaccine Breakthrough Infections Reveals Limited Infectious Virus Shedding and Restricted Tissue Distribution | Zendy

Ruian Ke | Zendy; Pamela P. Martinez | Zendy; Rebecca L. Smith | Zendy; Laura Gibson | Zendy; Chad J. Achenbach | Zendy; Sally M. McFall | Zendy; Chao Qi | Zendy; Joshua Jacob | Zendy; Etienne Dembele | Zendy; Camille Bundy | Zendy; Lacy M. Simons | Zendy; Egon A. Ozer | Zendy; Judd F. Hultquist | Zendy; Ramon LorenzoRedondo | Zendy; Anita Opdycke | Zendy; Claudia Hawkins | Zendy; Robert L. Murphy | Zendy; Agha Zeeshan Mirza | Zendy; Madison Conte | Zendy; Nicholas Gallagher | Zendy; Chun Huai Luo | Zendy; Junko Jarrett | Zendy; Abigail Conte | Zendy; Ruifeng Zhou | Zendy; Mireille Farjo | Zendy; Gloria Rendon | Zendy; Christopher J. Fields | Zendy; Leyi Wang | Zendy; Richard Fredrickson | Zendy; Melinda E. Baughman | Zendy; Karen Chiu | Zendy; Hannah Choi | Zendy; Kevin R. Scardina | Zendy; Alyssa N. Owens | Zendy; John Broach | Zendy; Bruce Barton | Zendy; Péter Lázár | Zendy; Matthew L. Robinson | Zendy; Heba H. Mostafa | Zendy; Yukari C. Manabe | Zendy; Andrew Pekosz | Zendy; David D. McManus | Zendy; Christopher B. Brooke | Zendy

Open Access

Longitudinal Analysis of SARS-CoV-2 Vaccine Breakthrough Infections Reveals Limited Infectious Virus Shedding and Restricted Tissue Distribution

Author(s) -

Ruian Ke,

Pamela P. Martinez,

Rebecca L. Smith,

Laura Gibson,

Chad J. Achenbach,

Sally M. McFall,

Chao Qi,

Joshua Jacob,

Etienne Dembele,

Camille Bundy,

Lacy M. Simons,

Egon A. Ozer,

Judd F. Hultquist,

Ramon LorenzoRedondo,

Anita Opdycke,

Claudia Hawkins,

Robert L. Murphy,

Agha Zeeshan Mirza,

Madison Conte,

Nicholas Gallagher,

Chun Huai Luo,

Junko Jarrett,

Abigail Conte,

Ruifeng Zhou,

Mireille Farjo,

Gloria Rendon,

Christopher J. Fields,

Leyi Wang,

Richard Fredrickson,

Melinda E. Baughman,

Karen Chiu,

Hannah Choi,

Kevin R. Scardina,

Alyssa N. Owens,

John Broach,

Bruce Barton,

Péter Lázár,

Matthew L. Robinson,

Heba H. Mostafa,

Yukari C. Manabe,

Andrew Pekosz,

David D. McManus,

Christopher B. Brooke

Publication year - 2022

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofac192

Subject(s) - viral shedding , medicine , vaccination , virus , virology , transmission (telecommunications) , pandemic , immunology , covid-19 , infectious dose , infectious disease (medical specialty) , disease , electrical engineering , engineering

Background The global effort to vaccinate people against SARS-CoV-2 during an ongoing pandemic has raised questions about how vaccine breakthrough infections compare with infections in immunologically naive individuals, and the potential for vaccinated individuals to transmit the virus. Methods We examined viral dynamics and infectious virus shedding through daily longitudinal sampling in 23 adults infected with SARS-CoV-2 at varying stages of vaccination, including 6 fully vaccinated individuals. Results The durations of both infectious virus shedding and symptoms were significantly reduced in vaccinated individuals compared with unvaccinated individuals. We also observed that breakthrough infections are associated with strong tissue compartmentalization and are only detectable in saliva in some cases. Interpretation Vaccination shortens the duration of time of high transmission potential, minimizes symptom duration, and may restrict tissue dissemination.

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