Associations Between Vancomycin Exposure and Acute Kidney Injury Within the Recommended Area Under the Curve Therapeutic Exposure Range Among Patients With Methicillin-Resistant Staphylococcus aureus Bloodstream Infections | Zendy

Thomas P. Lodise | Zendy; Marc H. Scheetz | Zendy; Joseph J. Carreno | Zendy; Henry F. Chambers | Zendy; Vance G. Fowler | Zendy; Thomas L Holland | Zendy

Open Access

Associations Between Vancomycin Exposure and Acute Kidney Injury Within the Recommended Area Under the Curve Therapeutic Exposure Range Among Patients With Methicillin-Resistant Staphylococcus aureus Bloodstream Infections

Author(s) -

Thomas P. Lodise,

Marc H. Scheetz,

Joseph J. Carreno,

Henry F. Chambers,

Vance G. Fowler,

Thomas L Holland

Publication year - 2022

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofab651

Subject(s) - medicine , vancomycin , staphylococcus aureus , methicillin resistant staphylococcus aureus , acute kidney injury , bloodstream infection , intensive care medicine , bacteria , biology , genetics

Among patients with methicillin-resistant Staphylococcus aureus bacteremia, vancomycin-associated acute kidney injury increased as a function of the day 2 area under the curve (AUC), even for daily AUCs within the recommended therapeutic range (400–600). Further data are needed to determine if daily AUCs <400 can be maintained without compromising efficacy.

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