Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study | Zendy

Timothy M. Rawson | Zendy; Richard Wilson | Zendy; Luke Moore | Zendy; Alasdair MacGowan | Zendy; Andrew Lovering | Zendy; Mark Bayliss | Zendy; Mathew Kyriakides | Zendy; Mark Gilchrist | Zendy; Jason A. Roberts | Zendy; William Hope | Zendy; Alison Holmes | Zendy

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Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study

Author(s) -

Timothy M. Rawson,

Richard Wilson,

Luke Moore,

Alasdair MacGowan,

Andrew Lovering,

Mark Bayliss,

Mathew Kyriakides,

Mark Gilchrist,

Jason A. Roberts,

William Hope,

Alison Holmes

Publication year - 2021

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofab573

Subject(s) - penicillin , volunteer , pharmacokinetics , medicine , dosing , population , pharmacology , antibiotics , microbiology and biotechnology , biology , agronomy , environmental health

This healthy volunteer study aimed to explore phenoxymethylpenicillin (penicillin-V) pharmacokinetics (PK) to support the planning of large dosing studies in adults. Volunteers were dosed with penicillin-V at steady state. Total and unbound penicillin-V serum concentrations were determined, and a base population PK model was fitted to the data.

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