Rapid Changes in Nasopharyngeal Antibiotic Resistance Gene Profiles After Short Courses of Antibiotics in a Pilot Study of Ambulatory Young Children | Zendy

Leigh M. Howard | Zendy; Keerti L. Dantuluri | Zendy; Nicole Soper | Zendy; Isaac Thomsen | Zendy; Carlos G. Grijalva | Zendy

Open Access

Rapid Changes in Nasopharyngeal Antibiotic Resistance Gene Profiles After Short Courses of Antibiotics in a Pilot Study of Ambulatory Young Children

Author(s) -

Leigh M. Howard,

Keerti L. Dantuluri,

Nicole Soper,

Isaac Thomsen,

Carlos G. Grijalva

Publication year - 2021

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofab519

Subject(s) - antibiotics , carriage , medicine , antibiotic resistance , staphylococcus aureus , microbiology and biotechnology , ambulatory , streptococcus pneumoniae , gene , bacteria , biology , genetics , pathology

We quantified antibiotic resistance genes before and after short antibiotic courses in nasopharyngeal specimens from ambulatory children. Carriage of certain bacteria and resistance genes was common before antibiotics. After antibiotics, we observed substantial reductions in pneumococcal and Staphylococcus aureus carriage and rapid expansion in the abundance of certain resistance genes.

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