English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Infections due to Gram-negative, diarrheal pathogens are a significant cause of morbidity in children. Clinical features of pediatric  Shigella  and  Campylobacter  infections in urban cities in the United States are not well described.    Methods  We used a retrospective chart review of records (0-18 years of age) from a network of hospitals in Houston, TX. Only patients with  Shigella  spp. or  Campylobacter  spp. isolated from clinical samples in 2019 and 2020 were included. Demographic, clinical, and microbiological data were extracted from the medical record.Results  We identified a total of 59 and 16 pediatric patients with  Shigella  spp. and  Campylobacter  spp. infections, respectively. Hospital admission occurred in 27.1% (16/59) of  Shigella  and 25% (4/16) of  Campylobacter.  Length of stay ranged between 1 and 2 days for both pathogens (Table 1). Of cases with available clinical data,  Shigella  infections were more likely to report fever during their illness compared to  Campylobacter  (80% versus 45.4%) (Table 2). Seizures were observed in 4  Shigella  infected patients. No episodes of  Shigella  or  Campylobacter  bacteremia were identified. Among patients with an identified exposure, daycare attendance and contact with individuals experiencing similar symptoms were most common (Table 2). The vast majority of  Shigella  species were  S. sonnei  (96.6%) and all  Campylobacter  were  C. jejuni  (Table 3). Resistance to trimethoprim-sulfamethoxazole (TMP-SMX) was common (40/55, 72.7%) among  Shigella  isolates tested. No resistance to fluoroquinolones or third generation cephalosporins in any of the  Shigella  spp. isolates was observed. Susceptibility testing was not performed in  Campylobacter  due to lack of isolates. The most frequent antibiotic used was azithromycin (in 73.3% and 75% of patients with  Shigella  and  Campylobacter,  respectively). Major complications included urinary tract infection (n=1), rectal prolapse (n=1) and splenomegaly (n=1).Conclusion  Infections due to  Shigella  and  Campylobacter  were a significant burden among pediatric patients between 2019 and 2020 in Houston, TX. The observed high frequency of resistance to TMP-SMX and emergence of multi-drug resistant  Shigella  in other countries warrants continued surveillance.Disclosures    Anthony R. Flores, MD, MPH, PhD , Nothing to disclose  Cesar A. Arias, M.D., MSc, Ph.D., FIDSA ,  Entasis Therapeutics  (Grant/Research Support) MeMed Diagnostics  (Grant/Research Support) Merk  (Grant/Research Support)

698. Contemporary Clinical Epidemiology of Pediatric Shigella and Campylobacter Infections in Houston, TX, 2019 and 2020