Coronavirus Disease 2019 in a Patient With a Systemic Autoinflammatory Syndrome due to an NLRC4 Inflammasomopathy | Zendy

Jeffrey K. Duncan-Lowey | Zendy; Vaidehi Chowdhary | Zendy; Dana Dunne | Zendy

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Coronavirus Disease 2019 in a Patient With a Systemic Autoinflammatory Syndrome due to an NLRC4 Inflammasomopathy

Author(s) -

Jeffrey K. Duncan-Lowey,

Vaidehi Chowdhary,

Dana Dunne

Publication year - 2021

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofab362

Subject(s) - medicine , nlrc4 , coronavirus , covid-19 , inflammasome , disease , immunosuppression , immunology , inflammation , caspase 1 , infectious disease (medical specialty)

The effect of autoinflammatory diseases on severe acute respiratory syndrome coronavirus 2 infection remains unknown. We report a case of coronavirus disease 2019 (COVID-19) in a patient with autoinflammation with infantile enterocolitis with inflammatory flares due to a mutation in the inflammasome component NLRC4. This case highlights the role of immunosuppression in patients with autoinflammation with COVID-19.

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