Open AccessRelapsed Babesia microti Infection Following Allogeneic Hematopoietic Cell Transplantation in a Patient With B-cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature
Author(s) -
Joshua Rosenblatt,
Annie Leung,
Emily Baneman,
Risa Fuller,
Sarah Taimur,
Alberto PanizMondolfi,
Adriana K. Malone,
Laura A. Kirkman,
Samantha E. Jacobs
Publication year - 2021
Publication title -
open forum infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.546
H-Index - 35
ISSN - 2328-8957
DOI - 10.1093/ofid/ofab323
Subject(s) - atovaquone , medicine , babesiosis , acute leukemia , leukemia , hematopoietic stem cell transplantation , transplantation , immunology , babesia , pneumonia , virology , malaria , plasmodium falciparum
A patient with relapsed/refractory B-cell acute lymphoblastic leukemia developed babesiosis before allogeneic hematopoietic cell transplantation while on atovaquone for Pneumocystis jirovecii pneumonia prophylaxis. Despite receiving a prolonged course of atovaquone and azithromycin until whole-blood Babesia microti DNA was no longer detected by polymerase chain reaction, her post-transplant course was complicated by relapsed babesiosis. We investigate the potential host and parasite characteristics causing relapsing/persistent infection.