Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution | Zendy

Ida Monrad | Zendy; Signe Risgaard Sahlertz | Zendy; Stine Sofie Frank Nielsen | Zendy; Louise Ørnskov Pedersen | Zendy; Mikkel Steen Petersen | Zendy; Carl M. Kobel | Zendy; Irene Harder Tarpgaard | Zendy; Merete Storgaard | Zendy; Klaus Leth Mortensen | Zendy; Mariane H. Schleimann | Zendy; Martin Tolstrup | Zendy; Line K. Vibholm | Zendy

Open Access

Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution

Author(s) -

Ida Monrad,

Signe Risgaard Sahlertz,

Stine Sofie Frank Nielsen,

Louise Ørnskov Pedersen,

Mikkel Steen Petersen,

Carl M. Kobel,

Irene Harder Tarpgaard,

Merete Storgaard,

Klaus Leth Mortensen,

Mariane H. Schleimann,

Martin Tolstrup,

Line K. Vibholm

Publication year - 2021

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofab295

Subject(s) - medicine , coronavirus , respiratory system , virology , covid-19 , immunology , disease , infectious disease (medical specialty)

We report a coronavirus disease 2019 case with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persisting beyond 333 days in an immunocompromised patient with chronic lymphocytic leukemia, asymptomatically carrying infectious SARS-CoV-2 at day 197 postdiagnosis. In addition, viral sequencing indicates major changes in the spike protein over time, temporally associated with convalescent plasma treatment.

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