IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis | Zendy

Isaiah R. Turnbull | Zendy; Monty B. Mazer | Zendy; Mark H. Hoofnagle | Zendy; John P. Kirby | Zendy; Jennifer Leonard | Zendy; Carlos Mejía-Chew | Zendy; Andrej Spec | Zendy; Jane Blood | Zendy; Sydney Miles | Zendy; Eric M. Ransom | Zendy; Robert F. Potter | Zendy; Joseph P. Gaut | Zendy; Kenneth E. Remy | Zendy; Richard S. Hotchkiss | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis

Author(s) -

Isaiah R. Turnbull,

Monty B. Mazer,

Mark H. Hoofnagle,

John P. Kirby,

Jennifer Leonard,

Carlos Mejía-Chew,

Andrej Spec,

Jane Blood,

Sydney Miles,

Eric M. Ransom,

Robert F. Potter,

Joseph P. Gaut,

Kenneth E. Remy,

Richard S. Hotchkiss

Publication year - 2021

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofab256

Subject(s) - medicine , immunotherapy , immunity , sepsis , debridement (dental) , immunology , antifungal , immune system , dermatology , surgery

A nonimmunocompromised patient developed life-threatening soft tissue infection with Trichosporon asahii, Fusarium, and Saksenaea that progressed despite maximum antifungal therapies and aggressive debridement. Interleukin-7 immunotherapy resulted in clinical improvement, fungal clearance, reversal of lymphopenia, and improved T-cell function. Immunoadjuvant therapies to boost host immunity may be efficacious in life-threatening fungal infections.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research