Detection of Free Toxin B in the Stool of Asymptomatic Clostridioides difficile Carriers by the Cell Cytotoxicity Neutralization Assay | Zendy

Lorne Schweitzer | Zendy; Phillippe Gervais | Zendy; Bianka Paquet-Bolduc | Zendy; Vivian G. Loo | Zendy; Yves Longtin | Zendy

Open Access

Detection of Free Toxin B in the Stool of Asymptomatic Clostridioides difficile Carriers by the Cell Cytotoxicity Neutralization Assay

Author(s) -

Lorne Schweitzer,

Phillippe Gervais,

Bianka Paquet-Bolduc,

Vivian G. Loo,

Yves Longtin

Publication year - 2021

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofab209

Subject(s) - asymptomatic , medicine , asymptomatic carrier , clostridioides , neutralization , cytotoxicity , toxin , microbiology and biotechnology , virology , in vitro , biology , biochemistry , virus

Cell cytotoxicity neutralization assay (CCNA) is considered to be a gold standard to diagnose Clostridioides difficile infections. We performed CCNA on 77 consecutive admission screening rectal swabs from asymptomatic toxigenic C. difficile carriers. Thirty-nine percent of specimens from asymptomatic carriers were positive. Thus, CCNA specificity may be lower than previously thought.

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