Time to SARS-CoV-2 PCR Clearance in Immunocompromising Conditions: Is Test-Based Removal From Isolation Necessary in Severely Immunocompromised Individuals? | Zendy

Rachel Epstein | Zendy; Heather Sperring | Zendy; Melissa Hofman | Zendy; Sara Lodi | Zendy; Laura F. White | Zendy; Joshua A. Barocas | Zendy; Tara C. Bouton | Zendy; Yian Xiao | Zendy; Heather Hsu | Zendy; Nancy S. Miller | Zendy; Benjamin P. Linas | Zendy; Jai Marathe | Zendy

Open Access

Time to SARS-CoV-2 PCR Clearance in Immunocompromising Conditions: Is Test-Based Removal From Isolation Necessary in Severely Immunocompromised Individuals?

Author(s) -

Rachel Epstein,

Heather Sperring,

Melissa Hofman,

Sara Lodi,

Laura F. White,

Joshua A. Barocas,

Tara C. Bouton,

Yian Xiao,

Heather Hsu,

Nancy S. Miller,

Benjamin P. Linas,

Jai Marathe

Publication year - 2021

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofab164

Subject(s) - medicine , covid-19 , isolation (microbiology) , virology , test (biology) , intensive care medicine , immunology , bioinformatics , outbreak , biology , disease , infectious disease (medical specialty) , paleontology

To determine the association between immunosuppression and time to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) clearance, we studied 3758 adults retested following initial SARS-CoV-2 infection. Cox proportional hazards models demonstrated delayed PCR clearance with older age, multiple comorbidities, and solid organ transplant but not by degree of immunocompromise. These findings challenge current retesting practices.

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