CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants | Zendy

Andrew D. Redd | Zendy; Alessandra Nardin | Zendy; Hassen Kared | Zendy; Evan M. Bloch | Zendy; Andrew Pekosz | Zendy; Oliver Laeyendecker | Zendy; Bernd Abel | Zendy; Michael Fehlings | Zendy; Thomas C. Quinn | Zendy; Aaron A.R. Tobian | Zendy

Open Access

CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants

Author(s) -

Andrew D. Redd,

Alessandra Nardin,

Hassen Kared,

Evan M. Bloch,

Andrew Pekosz,

Oliver Laeyendecker,

Bernd Abel,

Michael Fehlings,

Thomas C. Quinn,

Aaron A.R. Tobian

Publication year - 2021

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofab143

Subject(s) - covid-19 , virology , medicine , epitope , betacoronavirus , pandemic , sars virus , immunology , antibody , outbreak , pathology , disease , infectious disease (medical specialty)

This study examined whether CD8+ T-cell responses from coronavirus disease 2019 convalescent individuals (n = 30) potentially maintain recognition of the major severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants (alpha, beta, gamma; n = 45 mutations assessed). Only 1 mutation found in Beta variant-spike overlapped with a previously identified epitope (1/52), suggesting that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants.

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