Diabetes Mellitus and Tuberculosis Treatment Outcomes in Pune, India | Zendy

Vidya Mave | Zendy; Sanjay Gaikwad | Zendy; M.S. Barthwal | Zendy; Ajay Chandanwale | Zendy; Rahul Lokhande | Zendy; Dileep Kadam | Zendy; Sujata Dharmshale | Zendy; Renu Bharadwaj | Zendy; Anju Kagal | Zendy; Neeta Pradhan | Zendy; Sona Deshmukh | Zendy; Sachin Atre | Zendy; Tushar Sahasrabudhe | Zendy; Shailesh Bhanudas Meshram | Zendy; Kakrani Al | Zendy; Vandana Kulkarni | Zendy; Swapnil Raskar | Zendy; Nishi Suryavanshi | Zendy; Hardy Kornfeld | Zendy; Kelly E. Dooley | Zendy; Sandy Chon | Zendy; Akshay Gupte | Zendy; Amita Gupta | Zendy; Nikhil Gupte | Zendy; Jonathan E. Golub | Zendy

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Diabetes Mellitus and Tuberculosis Treatment Outcomes in Pune, India

Author(s) -

Vidya Mave,

Sanjay Gaikwad,

M.S. Barthwal,

Ajay Chandanwale,

Rahul Lokhande,

Dileep Kadam,

Sujata Dharmshale,

Renu Bharadwaj,

Anju Kagal,

Neeta Pradhan,

Sona Deshmukh,

Sachin Atre,

Tushar Sahasrabudhe,

Shailesh Bhanudas Meshram,

Kakrani Al,

Vandana Kulkarni,

Swapnil Raskar,

Nishi Suryavanshi,

Hardy Kornfeld,

Kelly E. Dooley,

Sandy Chon,

Akshay Gupte,

Amita Gupta,

Nikhil Gupte,

Jonathan E. Golub

Publication year - 2021

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofab097

Subject(s) - medicine , hazard ratio , tuberculosis , diabetes mellitus , prospective cohort study , cohort study , retrospective cohort study , disease , proportional hazards model , confidence interval , pathology , endocrinology

Background Diabetes mellitus (DM) increases the risk of tuberculosis (TB) disease. Knowledge of the impact of DM on TB treatment outcomes is primarily based on retrospective studies. Methods We conducted a prospective cohort study of new pulmonary TB patients with and without DM (TB-DM and TB only) in India. The association of DM with a composite unfavorable TB treatment outcome (failure, recurrence, mortality) over 18 months was determined, and the effect of DM on all-cause mortality and early mortality (death during TB treatment) was assessed. Results Of 799 participants, 574 (72%) had TB only and 225 (28%) had TB-DM. The proportion of patients with DM who experienced the composite outcome was 20%, as compared with 21% for TB-only participants (adjusted hazard ratio [aHR], 1.13; 95% CI, 0.75–1.70). Mortality was higher in participants with DM (10% vs 7%), and early mortality was substantially higher among patients with DM (aHR, 4.36; 95% CI, 1.62–11.76). Conclusions DM was associated with early mortality in this prospective cohort study, but overall unfavorable outcomes were similar to participants without DM. Interventions to reduce mortality during TB treatment among people with TB-DM are needed.

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