Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection | Zendy

Amy C Sherman | Zendy; Xiaoyan Lu | Zendy; Eileen Schneider | Zendy; Amelia Langston | Zendy; Carla L. Ellis | Zendy; Stephen O. Pastan | Zendy; Julu Bhatnagar | Zendy; Sarah Reagan-Steiner | Zendy; Pallavi Annambhotla | Zendy; Stephen Lindstrom | Zendy; Aneesh K. Mehta | Zendy; Stephanie M. Pouch | Zendy; Marybeth Sexton | Zendy

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Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection

Author(s) -

Amy C Sherman,

Xiaoyan Lu,

Eileen Schneider,

Amelia Langston,

Carla L. Ellis,

Stephen O. Pastan,

Julu Bhatnagar,

Sarah Reagan-Steiner,

Pallavi Annambhotla,

Stephen Lindstrom,

Aneesh K. Mehta,

Stephanie M. Pouch,

Marybeth Sexton

Publication year - 2021

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofab092

Subject(s) - medicine , renal transplant , transplantation , virology , immunology

Background Human adenovirus (HAdV) infections can lead to high mortality in solid organ transplant (SOT) recipients, with rare reports of donor-derived infection. Methods Two renal transplant recipients with HAdV-11 infection who received kidneys from the same donor are described. Whole-genome sequencing (WGS) was performed. Results WGS showed 100% nucleotide sequence identity for the 2 HAdV-11 isolates. The patients presented with distinct clinical syndromes, and both were treated with brincidofovir. Conclusions Donor-derived HAdV infection is presumed to be low; however, disseminated HAdV in SOT recipients can be severe, and clinicians should be aware of the clinical course and treatment options.

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