Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis | Zendy

Síle F. Molloy | Zendy; B.A. Ross | Zendy; Cecilia Kanyama | Zendy; Sayoki Mfinanga | Zendy; Sokoine Lesikari | Zendy; Robert S. Heyderman | Zendy; Newton Kalata | Zendy; Jayne Ellis | Zendy; Charles Kouanfack | Zendy; Duncan Chanda | Zendy; Elvis Temfack | Zendy; Shabir Lakhi | Zendy; Anand Moodley | Zendy; Adrienne K Chan | Zendy; Joep J. van Oosterhout | Zendy; Yacouba Njankouo Mapoure | Zendy; Peter Mwaba | Zendy; David G. Lalloo | Zendy; Duolao Wang | Zendy; Olivier Lortholary | Zendy; Shabbar Jaffar | Zendy; Mina C. Hosseinipour | Zendy; Angela Loyse | Zendy; Thomas S. Harrison | Zendy; Tihana Bicanic | Zendy

Open Access

Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis

Author(s) -

Síle F. Molloy,

B.A. Ross,

Cecilia Kanyama,

Sayoki Mfinanga,

Sokoine Lesikari,

Robert S. Heyderman,

Newton Kalata,

Jayne Ellis,

Charles Kouanfack,

Duncan Chanda,

Elvis Temfack,

Shabir Lakhi,

Anand Moodley,

Adrienne K Chan,

Joep J. van Oosterhout,

Yacouba Njankouo Mapoure,

Peter Mwaba,

David G. Lalloo,

Duolao Wang,

Olivier Lortholary,

Shabbar Jaffar,

Mina C. Hosseinipour,

Angela Loyse,

Thomas S. Harrison,

Tihana Bicanic

Publication year - 2021

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofab066

Subject(s) - medicine , meningitis , odds ratio , confidence interval , cryptococcosis , cryptococcal meningitis , cerebrospinal fluid , human immunodeficiency virus (hiv) , immunology , surgery , viral disease

Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH 2 O (adjusted odds ratio [aOR], 2.56; 95% confidence interval [CI], 1.36–4.83; P = .02) and fungal burden >6.0 log 10 colonies/mL (aOR, 3.01; 95% CI, 1.58–5.7; P = .003) were independently associated with severe visual loss.

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