Open AccessLow Cycle Threshold Value in Xpert MTB/RIF Assay May Herald False Detection of Tuberculosis and Rifampicin Resistance: A Study of Two Cases
Author(s) -
Jean Claude Semuto Ngabonziza,
Tom Decroo,
Rodrigue Maniliho,
Yves Mucyo Habimana,
Armand Van Deun,
Bouke C. de Jong
Publication year - 2021
Publication title -
open forum infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.546
H-Index - 35
ISSN - 2328-8957
DOI - 10.1093/ofid/ofab034
Subject(s) - medicine , rifampicin , tuberculosis , mycobacterium tuberculosis , virology , genexpert mtb/rif , pathology
We report 2 cases for whom Xpert MTB/RIF falsely signaled rifampicin-resistant tuberculosis, based on unusually low cycle threshold and 3 of 5 probes missing. Other mycobacterial tests were negative. Further optimization of the Xpert MTB/RIF algorithm is warranted.
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