Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases | Zendy

Heather W Dolby | Zendy; Philippe MD Potey | Zendy; Annika Beate Wilder-Smith | Zendy; Sara Clohisey | Zendy; Jonathan Millar | Zendy; J. Kenneth Baillie | Zendy; David A. Dorward | Zendy; Christopher D. Lucas | Zendy; Clark D Russell | Zendy

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Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases

Author(s) -

Heather W Dolby,

Philippe MD Potey,

Annika Beate Wilder-Smith,

Sara Clohisey,

Jonathan Millar,

J. Kenneth Baillie,

David A. Dorward,

Christopher D. Lucas,

Clark D Russell

Publication year - 2020

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofaa640

Subject(s) - medicine , vasculitis , respiratory system , intensive care medicine , pathology , disease

Pulmonary microthrombosis and vasculitis occur in fatal coronavirus disease 2019. To determine whether these processes occur in other life-threatening respiratory virus infections, we identified autopsy studies of fatal influenza (n = 455 patients), severe acute respiratory syndrome ([SARS] n = 37), Middle East respiratory syndrome (n = 2), adenovirus (n = 34), and respiratory syncytial virus (n = 30). Histological evidence of thrombosis was frequently present in adults with fatal influenza and SARS, with vasculitis also reported.

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